012 - ANA Comprehensive Autoimmune Panel, No Screen (11 tests)

11 ANA Components (no ANA Screen)

PROVIDER INITIATED TEST - The ANA Comprehensive Autoimmune Panel, No Screen, is an 11-component blood test that evaluates specific ANA-associated autoantibodies commonly seen in autoimmune and connective tissue disorders. Unlike a traditional ANA panel, this test does not include an initial ANA screen and instead focuses directly on individual antibody components that provide more targeted diagnostic insight. This panel is typically ordered when an ANA screen is already positive or when there is a strong clinical suspicion of autoimmune disease. Measuring specific autoantibodies can help further clarify immune system activity and support evaluation of conditions such as lupus, Sjögren’s syndrome, scleroderma, mixed connective tissue disease, and inflammatory muscle disorders. The panel includes 11 tests: Anti-dsDNA: Often associated with systemic lupus erythematosus (SLE) Chromatin Antibodies: Linked to lupus and other autoimmune conditions Ribosomal P Antibodies: Associated with lupus, including neurologic involvement Sjogren’s Antibodies (SS-A / SS-B): Common in Sjögren’s syndrome and lupus Smith (Sm) Antibodies: Highly specific for lupus Sm/RNP Antibodies: Seen in mixed connective tissue disease RNP Antibodies: Associated with connective tissue disorders Centromere B Antibodies: Often linked to limited systemic sclerosis Scleroderma Antibodies (Scl-70): Associated with systemic sclerosis Jo-1 Antibodies: Linked to inflammatory muscle diseases (NOTE: This panel does NOT include an ANA screening test.)