PROVIDER INITIATED TEST - The Scl-70 Antibodies test measures antibodies directed against topoisomerase I, a nuclear enzyme involved in DNA replication. These antibodies are most commonly associated with systemic sclerosis (scleroderma), particularly the diffuse form of the disease.
This test is typically ordered as part of an ANA component or autoimmune evaluation when symptoms such as skin thickening, Raynaud’s phenomenon, joint pain, shortness of breath, or unexplained fibrosis are present. Results are interpreted alongside other autoimmune markers and clinical findings to support diagnosis and disease classification.
Scl-70 Abs
PROVIDER INITIATED TEST - The Scl-70 Antibodies test measures antibodies directed against topoisomerase I, a nuclear enzyme involved in DNA replication. These antibodies are most commonly associated with systemic sclerosis (scleroderma), particularly the diffuse form of the disease.
This test is typically ordered as part of an ANA component or autoimmune evaluation when symptoms such as skin thickening, Raynaud’s phenomenon, joint pain, shortness of breath, or unexplained fibrosis are present. Results are interpreted alongside other autoimmune markers and clinical findings to support diagnosis and disease classification.
